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2 C - Traduzir

Exosome Therapeutics Market Professional Survey Report by 2035

In recent years, therapies utilizing extracellular vesicles have garnered significant attention among the industry stakeholders for the treatment of diverse target indication, primarily owing to the various benefits offered by them, including target specificity, enhanced tissue regeneration, and reduced inflammation and chronic pain.

Over time, various research studies have demonstrated the potential of exosomes (membrane bound extracellular vesicles) in disease diagnosis, drug delivery and therapeutic applications. As a result, exosome therapeutics domain has been gaining traction recently.

INTRODUCTION TO EXOSOMES
Exosomes are extracellular vesicles, which have endosomal origin and may contain different biomolecules, including proteins, DNA, lipids, miRNA or RNA, based on the type of cell of their origin and its conditions.
Exosomes convey a wide range of information to the target cells, depending on their source. In addition, they are involved in regulating the expression of the targets that are linked to RNA as they can affect the expression of RNA.

TYPES OF EXTRACELLULAR VESICLES
Micro-vesicles have size of about 100 nm and are formed by direct outward budding of the plasma membrane. Their formation solely depends on the surrounding environment and this process requires the presence of cytoskeleton components, namely actin/
Exosomes have a diameter in the range between 30-150 nm and are formed by inward budding and get developed into the multivesicular bodies (MVBs). Owing to their long half-life, exosomes can target specific organs of the body, which makes them widely studied vesicles for immunological purposes.
Apoptotic bodies have a diameter of about 5,000 nm and formed after the separation of plasma membrane from the skeleton. They can be easily distinguished from micro vesicles and exosomes because of their unscathed organelles as well as chromatin.

EXOSOME BIOGENESIS, FORMATION, DEVELOPMENT AND SECRETION
Exosomes are known to arise from the inward folding of multi-vesicular bodies (MVBs) in order to form the intraluminal vesicles (ILVs).
These MVBs are then delivered to the trans-Golgi network (TGN) for the recovery of endosomes, which further move to lysosome for degeneration of the carried substances. The most essential component of exosome biogenesis is the formation of ESCRT.

Formation and development of exosomes:
 Sorting of internalized cargoes into early endosomes
 Maturation into late endosomes or multivesicular bodies
 Delivery of cargoes from trans-Golgi network and cytosol
 Exosomes cargo in multivesicular bodies are transported to plasma membrane
 Fusion with the plasma membrane
 Secretion of exosomes

ADVANTAGES AND FUTURE POTENTIAL OF EXOSOME THERAPEUTICS:
Advantages:
 High Compatibility: Exosomes are naturally occurring compounds that can withstand digestive enzymes.
 Low Immunogenicity: Due to the innate properties of exosomes including their potential tissue of cell selectivity.
 Targeted Drug Delivery: Ability to cross blood brain barrier cause lesser systemic effects and low toxicity.
Future Potential:
 Several emerging players have undertaken initiatives to explore the potential of exosomes for diagnosis of various diseases.
 Application of exosomes as biomarker or vector of various potential therapeutic molecules, represents a theragnostic approach.
 Advanced exosome technologies are being developed to fully substructure the potential therapeutic applications of exosomes.

For additional details, please visit https://www.rootsanalysis.com/....blog/introduction-to

You may also be interested in the following titles:
1. Smart Labels Market: Industry Trends and Global Forecasts, 2022-2035
2. AI-based Digital Pathology / AI Pathology Market: Industry Trends and Global Forecasts, 2022-2035

About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

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berry_cristan
2 C - Traduzir

Unlocking the Potential of Digital Twins in Healthcare: Benefits, Challenges and Opportunities

The application of digital twins in healthcare has the potential to revolutionize patient care, improve clinical outcomes, and reduce costs.
Digital twins, or virtual replicas of physical objects and environments, are being used in many different industries, and healthcare is no exception. In healthcare, these can be used to provide better patient monitoring, improve remote care, and create personalized treatments.

What is a Digital Twin?
Digital twins are virtual representations of real-world objects. A digital twin is a piece of equipment, for example, may have the same functionality as the physical counterpart. Digital twins can be created using a wide range of data sources, such as sensors, models, and images. In the context of healthcare, these technologies can include the full representation of a patient’s medical history, symptoms, current treatment, and even biometric data, such as blood pressure and heart rate.

Benefits Associated with The Use of Digital Twins
Digital twins offer many benefits to the healthcare industry. In the following sections, we explore the top three benefits offered by digital twin technologies.
• Real-Time Data Access – While physical objects can be monitored and controlled, the data is often delayed. A digital twin, on the other hand, can be almost immediately updated with data. This means that healthcare providers can see and respond to real-time changes / real world evidence and abnormalities.
• Improved Remote Care – Remote care is when healthcare is provided to patients who are not physically in a healthcare facility. Remote care is growing in popularity, but it comes with several challenges, such as a lack of real-time data and an inability to supervise the patient. Digital twins can help with these challenges by providing real-time data and allowing healthcare providers to view the patient remotely (telemedicine support).

Disadvantages Associated with The Use of Digital Twins
For all the benefits of digital twins, there are still some challenges that need to be addressed. In the following sections, we explore the top three challenges.
• Difficulty in Adoption – Digital twins have been in use since the early 2000s, but they have only recently started to be used in healthcare. This is largely due to the fact that digital twins have been primarily used in industrial settings and that the concept has been hard for healthcare providers to grasp. While many find the concept of a digital twin attractive, it has been challenging for healthcare providers to adopt the concept.
• Possibility of False Information – When data is fed into a digital twin, it can be inaccurate or incomplete. This can lead to incorrect findings and incorrect treatment plans. However, there are some efforts underway to solve this problem. One approach is to make the data used to create the digital twin as accurate as possible. Another approach is to let the digital twin correct itself based on new data.


Future Perspectives
In the following sections, we explore three ways in which the use of digital twins in healthcare can be improved.
• Better Adoption Rates – With better adoption rates, healthcare providers will be able to use digital twins to their full potential. With the help of vendors and organizations, such as the Industrial Internet Consortium, healthcare providers can be better informed about the advantages of digital twins.

Despite their immense rise in popularity, digital twins still have some issues that need to be resolved. As such, there are some ways in which the use of digital twins in healthcare can be improved.

For additional details, please visit https://www.rootsanalysis.com/....blog/digital-twins-i

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1. Smart Labels Market: Industry Trends and Global Forecasts, 2022-2035
2. AI-based Digital Pathology / AI Pathology Market: Industry Trends and Global Forecasts, 2022-2035

About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

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berry_cristan
2 C - Traduzir

Investment Opportunities in Women’s Digital Health

Digital health is a broad term that refers to the utilization of communication and information technologies to manage, track, and improve the overall healthcare delivery system.

Owing to the potential of digital technology to optimize patient healthcare and the development of pharmaceuticals, the digital healthcare industry has witnessed significant rise in investments in the past decade, including in the women’s digital health space. It is worth noting that the digital health initiative is mainly focused on developing and providing a range of easy-to-use and innovative tools to patients, scientists / researchers, healthcare professionals, and other industry stakeholders for better health management. A significant increase in adoption of digital solutions has been witnessed in this field, especially after the outbreak of pandemic.
Over the years, several initiatives have been undertaken by various industry stakeholders across the globe to promote digital health solutions and their applications. For instance, in 2019, the Preventive Healthcare tool was launched by Facebook to connect people to different health resources, enabling its users to set reminders for checkups, schedule tests and track their past activity.

Women’s Digital Health
Women’s digital health or FemTech is a broad industry that offers various products, services, diagnostic tools, wearable devices, software, applications and technologies in order to address the issues associated with women’s health, including menstrual, reproductive, sexual, maternity, and menopause disorders. Since it is primarily focused on women’s healthcare, it has been termed as Female Technology or FemTech.
In the past few years, several investments have been made by various institutional investors in the companies associated with women’s digital health sector. For instance, in April 2022, USD 28.5 million was raised by Evernow in venture series A for re-defining the menopause treatment. Additionally, in February 2022, USD 15 million was raised by Ro in venture series E to expand its direct-to-patient healthcare model.

Key Application Areas of FemTech Industry
The FemTech industry provides an opportunity for better self-management, enabling and empowering women to be more in control of their own health and wellbeing.

Future Perspectives
Owing to the increased adoption rate of digital solutions and rise in the demand for telehealth services, the companies involved in the women’s digital health domain have witnessed a surge in the investment activity. Subsequently, capital investments worth more than USD 3 billion have been made in this domain, over the past few years. Nearly 90% of the capital invested in the companies has, so far, come in from venture capital funding; some companies have already gone public. Moreover, there is a high unmet need in certain areas, such as management of mental health, disease conditions, such as PCOS, endometriosis and disease which have high prevalence among women. In order to identify the gaps and unmet needs, it is important to develop customized and focused solutions, and establish policies that can help in increasing awareness about women’s health. Given the potential of digital health solutions, with the development of affordable and accessible digital technologies, the healthcare service industry is expected to witness noteworthy growth in the coming years. Furthermore, taking into consideration the ongoing efforts to develop solutions for existing unmet needs, we expect the women’s digital health market to present numerous lucrative investment opportunities in the future.
For additional details, please visit https://www.rootsanalysis.com/....blog/womens-digital-

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1. Quantum Computing in Drug Discovery Services Market : - Industry Trends and Global Forecasts, 2023-2035
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About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

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berry_cristan
3 C - Traduzir

Genotoxicity Testing: Unlocking the Future Safety Assessment Opportunities

Genotoxicity testing refers to the evaluation of detrimental effects of chemical or physical agents on the genetic processes and related hereditary material of living cells.

On the other hand, mutagenicity is the process of inducing irreversible and transmissible alterations in the genetic material of organisms either spontaneously or through mutagenic activity.

Disruption of the integrity and function of DNA at the gene or chromosomal level can lead to heritable mutations, resulting in genetic disorders, birth abnormalities, or cancer. Potential targets for DNA damage include somatic cells (confined to the exposed generation), germinal cells (potentially inherited effects), and mitochondria (detrimental to the exposed individual and progeny via maternal inheritance).

Detrimental Effects of Genotoxins and Mutagens
Genotoxins are chemical substances or radiations which causes genotoxicity leading to DNA or chromosomal damage, further leading to mutations. In eukaryotic organisms, damage to genetic material of somatic cell can lead to malignancy (cancer) whereas genetic damage to germ cells can result in heritable mutations that induce birth defects.

Mechanism of Genotoxicity / Mutagenicity
The interaction of genotoxins / mutagens with the structure of DNA causes damage to the genetic material. These genotoxic / mutagenic substances interact with the DNA structure at a specific base sequence, inducing deletion, mis-segregation, or non-disjunction, resulting in damage and mutation.

Techniques Used for Genotoxicity / Mutagenicity Testing
Genotoxins can be classified based on their effects into the following types:
• Carcinogens: These have the ability to cause cancer. Examples – Asbestos, Benzene, Vinyl chloride and Carbon tetrachloride
• Mutagens: These can induce mutations in the genetic material of an organism. Examples – Chloroform, Ethylene oxide, and Lead
• Teratogens: These agents cause birth defects, abnormalities, or developmental problems in the offspring. Examples – Carbon monoxide, Lead and Xylene

GENE MUTATION
Ames Test: It is used to evaluate an agent’s mutagenic potential by reversing mutations in the tester mutant bacteria (E. coli, Salmonella typhi), as well as its ability to synthesize an essential amino acid required for growth
MLA / HPRT: It is used to evaluate an agent’s mutagenic potential by reversing mutations in the tester mutant bacteria (E. coli, Salmonella typhi), as well as its ability to synthesize an essential amino acid required for growth
Mutation Assay: Transgenic rodent somatic and germ cell gene mutation assay specifies an in vivo assay that perceives gene mutation causing agents.
DNA DAMAGES
Comet Assay: The comet assay, also known as single cell gel electrophoresis (SCGE), is an efficient technique for identifying DNA strand breaks in a cell. It is used in molecular epidemiology, genotoxicity testing, and basic studies on DNA damage and repair.
CHROMOSOMAL DAMAGES
Chromosomal Aberration Test: The comet assay, also known as single cell gel electrophoresis (SCGE), is an efficient technique for identifying DNA strand breaks in a cell.
Micronucleus Test: The micronucleus identifies chemicals (liquid or solid) that lead to cytogenetic damage, resulting in the formation of micronuclei containing complete or lagging chromosomal segments.
Applications of Genotoxicity / Mutagenicity
Genotoxicity testing and mutagenicity testing can be employed in a wide range of industries. It detects the potential long-term effects of the compounds which are marketed without knowing their ability to affect human and environmental health.
Recent Development and Future Perspectives
Recent advancements in informatics and instrumentation technologies have facilitated the necessity to evaluate mutations and chromosomal damage caused by various chemicals.
For additional details, please visit https://www.rootsanalysis.com/....blog/genotoxicity-mu

You may also be interested in the following titles:

1. Quantum Computing in Drug Discovery Services Market : - Industry Trends and Global Forecasts, 2023-2035
2. Viral Clearance and Viral Testing Services Market : - Industry Trends and Global Forecasts, 2023-2035



About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

Genotoxicity Testing Opportunities Market | Blog

Genotoxicity testing refers to the evaluation of detrimental effects of chemical or physical agents on the genetic processes and related
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berry_cristan
3 C - Traduzir

Adeno-Associated Viral Vectors: Unlocking the Future Opportunities

Given the potential of gene therapies in targeting the underlying cause of a disease at cellular level, the demand for such therapies has increased considerably over the past few years.

Currently, more than 285 gene therapies are being evaluated in different phases of clinical development. Further, various gene therapy developers have raised more than USD 10 billion capital during the year 2021. With the growing interest in such therapies, the demand for novel delivery vectors has also increased. Among various gene delivery vectors available, adeno-associated viral vectors have emerged as one of the most efficient viral vectors. Till now, the USFDA has approved two adeno-associated viral vectors-based drugs, LUXTURNA® and ZOLGENSMA®.

In order to cater to the demand, close to 100 players, across the globe, have emerged for the development and manufacturing of adeno-associated viral vectors. In fact, a number of these companies also offer advanced technology platforms, enabling the processing of AAV vectors and related therapies across different scales of operation. Various industry and non-industry players are actively engaged in research and development of novel gene delivery technologies, which are safe and effective.

155+ Clinical Trials have been / are being conducted
The stakeholders have invested extensively in conducting clinical trials for evaluating the efficacy of the therapeutic candidates in the treatment of a variety of indications.

~4,300 Patent Filed / Granted in the Domain
Examples of leading industry stakeholders, in terms of most patent applications filed include Genzyme, Voyager Therapeutics, REGENXBIO, Baxalta and Spark Therapeutics.

200+ Partnerships and Collaborations signed in the Domain
The growing partnerships and collaborations signed between different stakeholders is indicative of the significant demand of vectors and related therapies from the past few years.

As projected by Roots Analysis, oncological disorders therapeutic area will have majority share in the adeno-associated viral vector market. As projected by Roots Analysis, the overall market of AAV vector manufacturers market is expected to expand in the coming years.

For additional details, please visit https://www.rootsanalysis.com/....blog/adeno-associate

You may also be interested in the following titles:
1. Smart Labels Market: Industry Trends and Global Forecasts, 2022-2035
2. AI-based Digital Pathology / AI Pathology Market: Industry Trends and Global Forecasts, 2022-2035

About Roots Analysis
Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights.

Contact:
Ben Johnson
+1 (415) 800 3415
Ben.johnson@rootsanalysis.com

Adeno-Associated Viral Vectors Market | Blog

Adeno-associated viral vectors are the leading platform for gene delivery for the treatment of a variety of human diseases.
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